AventaCell BioMedical is one of the world's top companies in the development of advanced human tissue-derived products for use in cell culture and tissue regeneration. Helios Bioscience is AventaCell's product family brand for its products used in cell culture and tissue regeneration.
AventaCell is the supplier of the UltraGRO™ family products (platelet lysate for replacing Fetal Bovine Serum (FBS), xeno-free) available in research and GMP quality. Their portfolio contains platelet lysate in different qualities which includes also fibrinogen depleted hPL and a family of various inactivated hPLs using gamma irradiation.
Overview of our products for AventaCell/Helios with the UltraGRO™ family.
Product Type
Product Group
Species
UltraGROTM Cell Culture Supplement (Human Platelet Lysate Growth Factor Mixture) - (AventaCell)
Cell Culture Tools
UltraGROTM Cell Culture Supplement (Human Platelet Lysate Growth Factor Mixture) - (AventaCell)
Cell Culture Tools
UltraGROTM Cell Culture Supplement (Human Platelet Lysate Growth Factor Mixture) - (AventaCell)
Cell Culture Tools
UltraGROTM Cell Culture Supplement (Human Platelet Lysate Growth Factor Mixture) GMP Quality - (AventaCell)
Cell Culture Tools
UltraGROTM Cell Culture Supplement (Human Platelet Lysate Growth Factor Mixture) GMP Quality - (AventaCell)
Cell Culture Tools
UltraGROTM Cell Culture Supplement (Human Platelet Lysate Growth Factor Mixture) GMP Quality - (AventaCell)
Cell Culture Tools
UltraGROTM-Advanced Cell Culture Supplement (Fibrinogen-Depleted Human Platelet Lysate Growth Factor Mixture) - (AventaCell)
Cell Culture Tools
UltraGROTM-Advanced Cell Culture Supplement (Fibrinogen-Depleted Human Platelet Lysate Growth Factor Mixture) - (AventaCell)
Cell Culture Tools
UltraGROTM-Advanced Cell Culture Supplement (Fibrinogen-Depleted Human Platelet Lysate Growth Factor Mixture) - (AventaCell)
Cell Culture Tools
UltraGROTM-Advanced Cell Culture Supplement (Fibrinogen-Depleted Human Platelet Lysate Growth Factor Mixture), GMP Quality - (AventaCell)
Cell Culture Tools
UltraGROTM-Advanced Cell Culture Supplement (Fibrinogen-Depleted Human Platelet Lysate Growth Factor Mixture), GMP Quality - (AventaCell)
Cell Culture Tools
UltraGROTM-Advanced Cell Culture Supplement (Fibrinogen-Depleted Human Platelet Lysate Growth Factor Mixture), GMP Quality - (AventaCell)
Cell Culture Tools
HELIOS with UltraGRO™
The AventaCell technologies used in the Helios Bioscience product line provide innovative, human-derived solutions for use in translational research of cell- and tissue-based therapies that overcome the need for animal serum-free cell expansion and production. The need for secure, efficient and cost-effective cell expansion and production is rapidly increasing with the rise of research and clinical development in the areas of cell therapy and regenerative medicine.
Expansion and production of a broad range of cells including Mesenchymal Stem Cells.
Helios Bioscience's products are designed to accommodate the expansion and production of a broad range of cells, including mesenchymal stem cells and various immune cell lines. AventaCell's goal is to provide animal serum-free products to accelerate the research, development and commercialization of safe and effective cell- and tissue-based therapeutics.
References UltraGro™.
1. Scalable Manufacturing of Human Mesenchymal Stromal Cells in the Vertical-Wheel Bioreactor System: An Experimental and Economic Approach.
De Sousa Pinto D, Bandeiras C, de Almeida Fuzeta M, Rodrigues CAV, Jung S, Hashimura Y, Tseng RJ, Milligan W, Lee B, Ferreira FC, Lobato da Silva C, Cabral JMS. Biotechnol J. 2019 Aug;14(8):e1800716. doi: 10.1002/biot.201800716
2. A fully closed and automated hollow fiber bioreactor for clinical-grade manufacturing of human mesenchymal stem/stromal cells.
Amanda Mizukami, Mario Soares de Abreu Neto, Francisco Moreira, Ana Fernandes-Platzgummer, Yi-Feng Huang, William Milligan, Joaquim M. S. Cabral, Claudia L. da Silva, Dimas T. Covas, Kamilla Swiech. Stem Cell Rev. 2018;14(1):141-143. doi: 10.1007/ s12015-017-9787-4.
3. Transplantation routes affect the efficacy of human umbilical cord mesenchymal stem cells in a rat GDM model.
Dan Wu, Shan Zou, Haibin Chen, Xiaoyan Li, Yetao Xu, Qing Zuo, Yi Pan, Shi-Wen Jiang, Hung Huang Lizhou Sun. Clin Chim Acta. 2017;475:137-146. doi: 10.1016/j.cca.2017.10.013.
4. Integrated culture platform based on a human platelet lysate supplement for the isolation and scalable manufacturing of umbilical cord matrix-derived mesenchymal stem/stromal cells.
De Soure AM, Fernandes-Platzgummer A, Moreira F, Lilaia C, Liu SH, Ku CP, et al. J Tissue Eng Regen Med; 2017;11(5):1630-1640.
5. Human Platelet Lysate versus Fetal Calf Serum: These Supplements Do Not Select for Different Mesenchymal Stromal Cells.
Eduardo Fernandez-Rebollo, Birgit Mentrup, Regina Ebert, Julia Franzen, Giulio Abagnale, Torsten Sieben, Alina Ostrowska, Per Hoffmann, Pierre-François Roux, Björn Rath, Michele Goodhardt, Jean-Marc Lemaitre, Oliver Bischof, Franz Jakob & Wolfgang Wagner. Sci Rep. 2017 Jul 11;7(1):5132. doi: 10.1038/s41598-017-05207-1
6. Long-Term Expansion in Platelet Lysate Increases Growth of Peripheral Blood-Derived Endothelial-Colony Forming Cells and Their Growth Factor-Induced Sprouting Capacity.
Tasev D, van Wijhe MH, Weijers EM, van Hinsbergh VWM, Koolwijk P. PLoS One. 2015;10(6):e0129935
7. Evaluation of human platelet lysate versus fetal bovine serum for culture of mesenchymal stromal cells.
Hemeda H, Giebel B, Wagner W. Cytotherapy. 2014;16(2):170-80.
8. Human platelet lysate is a feasible candidate to replace fetal calf serum as medium supplement for blood vascular and lymphatic endothelial cells.
Cytotherapy. Hofbauer P, Riedl S, Witzeneder K, Hildner F, Wolbank S, Groeger M, et al. 2014;16(9):1238-44.
9. Human Wharton’s Jelly Mesenchymal Stem Cells Plasticity Augments Scar-Free Skin Wound Healing with Hair Growth.
Sabapathy V, Sundaram B, V M S, Mankuzhy P, Kumar S. PLoS One. 2014; 9(4):e93726.
10. The effect of platelet lysate fibrinogen on the functionality of MSCs in immunotherapy.
Copland IB, Garcia MA, Waller EK, Roback JD, Galipeau J. Biomaterials. 2013;34(32) : 7840-50.
11. Human platelet lysate stimulates high-passage and senescent human multipotent mesenchymal stromal cell growth and rejuvenation in vitro.
Griffiths S, Baraniak PR, Copland IB, Nerem RM, McDevitt TC. Cytotherapy. 2013; 15(12):1469-83.
12. Pooled human platelet lysate versus fetal bovine serum-investigating the proliferation rate, chromosome stability and angiogenic potential of human adipose tissue-derived stem cells intended for clinical use.
Trojahn Kølle SF, Oliveri RS, Glovinski PV, Kirchhoff M, Mathiasen AB, Elberg JJ, et al. Cytotherapy. 2013; 15(9):1086-97.
13. Manufacturing mesenchymal stromal cells for phase I clinical trials.
Hanley PJ, Mei Z, da Graca Cabreira-Hansen M, Klis M, Li W, Zhao Y, Durett AG, Zheng X, Wang Y, Gee AP, Horwitz EM. Cytotherapy. 2013;15(4):416-22.
14. Human platelets lysate as a promising growth-stimulating additive for culturing of stem cells and other cell types.
Shanskii YD, Sergeeva NS, Sviridova IK, Kirakozov MS, Kirsanova VA, Akhmedova SA, et al. Bull Exp Biol Med. 2013; 156(1):146-51.
15. Human platelet lysate as a fetal bovine serum substitute improves human adipose-derived stromal cell culture for future cardiac repair applications.
Naaijkens BA, Niessen HW, Prins HJ, Krijnen PA, Kokhuis TJ, de Jong N, et al. Cell Tissue Res. 2012; 348(1):119-30.
16. Platelet lysate from whole blood-derived pooled platelet concentrates and apheresis- derived platelet concentrates for the isolation and expansion of human bone marrow mesenchymal stromal cells: production process, content and identification of active components.
Fekete N, Gadelorge M, Fürst D, Maurer C, Dausend J, Fleury-Cappellesso S, et al. Cytotherapy. 2012; 14(5):540-54.
17. Phenotypical and functional characteristics of mesenchymal stem cells from bone marrow: comparison of culture using different media supplemented with human platelet lysate or fetal bovine serum.
Ben Azouna N, Jenhani F, Regaya Z, Berraeis L, Ben Othman T, Ducrocq E, et al. Stem Cell Research & Therapy. 2012, 3(1):6.
18. Human platelet lysate permits scale-up of dental pulp stromal cells for clinical applications.
Govindasamy V, Ronald VS, Abdullah AN, Ganesan Nathan KR, Aziz ZA, Abdullah M, et al. Cytotherapy. 2011;13(10):1221-33.
19. Alternatives to the use of fetal bovine serum: human platelet lysates as a serum substitute in cell culture media.
Rauch C, Feifel E, Amann EM, Spötl HP, Schennach H, Pfaller W, et al. ALTEX. 2011; 28(4) : 305-16.
20. Influence of Platelet Lysate on the Recovery and Metabolic Performance of Cryopreserved Human Hepatocytes Upon Thawing.
Tolosa L, Bonora-Centelles A, Donato MT, Mirabet V, Pareja E, Negro A, et al. Transplantation. 2011; 91(12):1340-6.
21. Platelet-lysate-Expanded Mesenchymal Stromal Cells as a Salvage Therapy for Severe Resistant Graft-versus-Host Disease in a Pediatric Population.
Lucchini G, Introna M, Dander E, Rovelli A, Balduzzi A, Bonanomi S, et al. Biol Blood Marrow Transplant. 2010; 16(9):1293-301.
22. Generation of mesenchymal stromal cells in the presence of platelet lysate: a phenotypic and functional comparison of umbilical cord blood- and bone marrow-derived progenitors.
Avanzini MA, Bernardo ME, Cometa AM, Perotti C, Zaffaroni N, Novara F, et al. Haematologica. 2009;94(12):1649-60.
23. Treatment of refractory acute GVHD with third-party MSC expanded in platelet lysate-containing medium.
von Bonin M, Stölzel F, Goedecke A, Richter K, Wuschek N, Hölig K, et al. Bone Marrow Transplant. 2009; 43(3):245-51.
24. Platelet lysate stimulates wound repair of HaCaT keratinocytes.
Ranzato E, Patrone M, Mazzucco L, Burlando B. Br J Dermatol. 2008;159(3):537-45.
25. Human platelet lysate allows expansion and clinical grade production of mesenchymal stromal cells from small samples of bone marrow aspirates or marrow filter washouts.
Capelli C, Domenghini M, Borleri G, Bellavita P, Poma R, Carobbio A, et al. Bone Marrow Transplant. 2007; 40, 785–791.
26. Platelet lysates promote mesenchymal stem cell expansion: a safety substitute for animal serum in cell-based therapy applications.
Doucet C, Ernou I, Zhang Y, Llense JR, Begot L, Holy X, et al. J Cell Physiol. 2005; 205(2):228-36.
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