Metatissue

Metatissue PELOBiotech GmbH

Metatissue provides human protein-based hydrogels, widely used in cell culture, tissue engineering, regeneration and disease modeling.

Metatissue specializes in creating human protein-based hydrogels, sponges, and bioinks for 3D cell culture, disease modeling, and personalized medicine. They aim to reduce animal testing by providing predictive and translatable in vitro models, enhancing drug development efficiency and supporting animal welfare.

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Metatissue PELOBiotech GmbH

Hplma

Supplier
Metatissue

Catalog Number
PB-PLL01-1000

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Metatissue PELOBiotech GmbH

Hplma

Supplier
Metatissue

Catalog Number
PB-PLL01-0500

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Metatissue PELOBiotech GmbH

Hplma

Supplier
Metatissue

Catalog Number
PB-PLL01-0100

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Advanced Extracellular Matrix solutions for cell culture and tissue engineering

Metatissue offers extracellular matrix (ECM) products sourced from metatissue, designed to provide realistic and human-like microenvironments for cell culture, tissue engineering, and disease modeling. Their ECM products are mechanically tuneable, photocrosslinkable, versatile, reproducible, and personalized to meet the diverse needs of your research.

hPCMA – Human Methacryloyl Placenta

A xeno-free, human placenta-derived ECM hydrogel for physiologically relevant 3D cell culture.

hPCMA is a methacrylated human placenta-derived biomaterial that recapitulates the native extracellular matrix environment for advanced in vitro applications. Its rich ECM composition — including Collagen types I, III, IV, and VI, Fibronectin, Laminin, Fibrinogen, Fibrillin, and more — makes it a powerful scaffold for supporting cell adhesion, growth, and proliferation in 3D.

Key Features:

  • Human protein-based, xeno-free formulation — no animal-derived serum or undefined components

  • Mechanically tunable hydrogels: stiffness can be adjusted by varying biomaterial concentration (0.7–1.3% w/v), enabling simulation of diverse tissue mechanics

  • Sterile lyophilized format with a controlled degree of methacrylation and ≤400 ng DNA/mg dry ECM

  • Photopolymerizable — rapid gelation upon UV/visible light exposure

  • Validated for long-term 3D culture: encapsulated hASCs maintain viability and proliferate for at least 7 days

Format: 100 mg lyophilized powder | Storage: 2–8°C | For research use only

hPLMA Easy – Ready-to-Use Photopolymerizable Hydrogel

A plug-and-play, xeno-free hydrogel derived from human platelet lysates — just add light.

hPLMA Easy is a bioactive, animal serum-free hydrogel platform designed to closely mimic the native extracellular environment. As a ready-to-use 15% (w/v) solution of methacrylated human platelet lysates (hPLMA) in PBS with 0.5% (w/v) LAP photoinitiator pre-incorporated, it eliminates reconstitution steps and dramatically reduces experimental variability. Exposure to light at 365–405 nm triggers rapid, reproducible polymerization into a stable hydrogel.

Key Features:

  • Xeno-free and animal serum-free — fully human-derived, ideal for translational and GMP-aligned workflows

  • Loaded with native bioactive factors including PDGF, VEGF, EPO, EGF, and HGF — key drivers of cell adhesion, proliferation, and angiogenesis

  • Soft tissue-like mechanical properties with a Young's modulus of ~15 kPa

  • Compatible with both extrusion-based (FRESH) and DLP 3D bioprinting

  • Validated 6-month shelf life at 4°C with consistent cell performance over time

  • Donor-screened raw material with full infectious disease testing panel (HBsAg, HIV, HCV, HBV, WNV, syphilis, and more)

Format: Ready-to-use liquid | Storage: 4°C, stable 6 months post-MFG | For research use only

Why Choose Metatissue ECM Products?

Mechanically tuneable: Metatissue's ECM products can be mechanically adjusted to mimic the stiffness and elasticity of various tissues, providing a more accurate in vitro environment.

Photocrosslinkable: Easily form hydrogels upon light exposure, allowing for precise control over the 3D structure and properties of the ECM.

Versatile: Suitable for a wide range of applications, including cell culture, tissue engineering, and disease modeling.

Reproducible: Consistent quality and performance across batches, ensuring reliable and reproducible results.

Personalized: Customizable to meet the specific requirements of your research projects.

Product Features

Ethically Sourced Human Proteins: Our ECM products are derived from ethically and readily available human sources, ensuring high biocompatibility and relevance to human biology.

Robust and Easy to Handle: Chemically modified to create robust materials that are easy to handle and manipulate in the lab.

Enhanced Cell Interactions: Designed to improve cell-to-cell and cell-to-matrix interactions, increasing the accuracy of in vitro studies.

Applications

Cell Culture: Provides a realistic microenvironment for cell growth and differentiation.

Tissue Engineering: Supports the development and regeneration of tissues in vitro.

Disease Modeling: Enables the creation of more accurate disease models for research and drug testing.

Benefits

Improved Research Accuracy: Mimics the extracellular matrix of living tissues, enhancing the correlation between laboratory research and clinical trials.

Reduction in Animal Testing: Provides a viable alternative to animal models, reducing the need for animal testing.

Accelerated Scientific Discoveries: Increases the speed of scientific discoveries by providing more accurate and reliable in vitro models.

Frequently Asked Questions

What are the main applications of Metatissue ECM products?

Our ECM products are used in cell culture, tissue engineering, and disease modeling to provide realistic and human-like microenvironments.

How are Metatissue ECM Products different from other ECM products?

Our ECM products are mechanically tuneable, photocrosslinkable, versatile, reproducible, and personalized, offering superior performance and customization options.