abc biopply

abc biopply PELOBiotech GmbH

abc biopply is an expert for 3D cell culture, 3D cell culture services and drug discovery.

The swiss contract research organization abc biopply is best known for its specialized 3D cell culture and 3D cell culture services, assays and its proprietary platform 3D CoSeedis™. This system allows you to obtain reliable quantitative datasets from cells and tissues easily. It helps advance your solutions in drug discoveries and advanced preclinical disease models.

Abc biopply provides a service that helps pharma and biotech companies boost the predictive power of their preclinical models and speed up their drug discovery efforts. With their dedicated 3D-CoSeedis™ cell culture technology, they are closing the gap between in vitro and in vivo studies by applying the next level of differentiation and intercellular communication assays.

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3D CoSeedis™ Co-Culture system.

All licenses for 3D CoSeedis™ assays contain various 3D CoSeedis™ chips and accessories. They can also be enhanced with media and other enhancement products extension products, depending on your needs and the particular assay. Licenses are available for single-packaged or multi-packaged chips. Academic partners, please ask for special conditions.

Speed up drug discovery

The company has developed a distinctive portfolio of 3D tissue imaging and analysis assays, all based on the novel flexibility of their 3D CoSeedis™ co-culture system, enabling the easy and reliable creation of quantitative datasets from tissues and cells.

abc biopply PELOBiotech GmbH

Improved predictive power of preclinical disease models

3D CoSeedis™ multi-organoid technology boosted the relevance of in vitro testing to the ex vivo level. Based on its own technology and extensive expertise in organoid biology, abc biopply has developed the company's portfolio of in-chip study models.

In-chip study models for drug development.

These models offer superior predictability in the preclinical evaluation of therapeutic targets by making the conditions for environmental drug resistance measurable to quality previously unknown. Thus, abc biopply's in-chip study models enable rapid pre-selection of compounds based on results that fully comply with FDA requirements for a microphysiological system. They increase the predictability of conventional models by removing the discovery burden of conventional pdx models and giving them a purely confirmatory character.

Facts about abc biopply. References.

Ex vivo propagation in a novel 3D high-throughput co-culture system for multiple myeloma
Johannes M. Waldschmidt et al., JCRCO, November 2021, https://doi.org/10.1007/s00432-021-03854-6

Immunophenotype of Gastric Tumors Unveils a Pleiotropic Role of Regulatory T Cells in Tumor Development
Sara Rocha et al., MDPI, January 2021, https://doi.org/10.3390/cancers13030421

Tumor Treating Fields (TTFields) Hinder Cancer Cell Motility through Regulation of Microtubule and Actin Dynamics
Tali Voloshin et al., MDPI, October 2020, https://doi.org/10.3390/cancers12103016

An Anti-PSMA Immunotoxin Reduces Mcl-1 and Bcl2A1 and Specifically Induces in Combination with the BAD-Like BH3 Mimetic ABT-737 Apoptosis in Prostate Cancer Cells
Anie P Masilamani et al., MDPI, June 2020, https://doi.org/10.3390/cancers12061648

Three-dimensional cell models for extracellular vesicles production, isolation, and characterization
Liliia Paniushkina et al., Methods in Enzymology, 2020, https://doi.org/10.1016/bs.mie.2020.09.005

Tspan8 is expressed in breast cancer and regulates E-cadherin / catenin signaling and metastasis accompanied by increased circulating extracellular vesicles
Maren Vogelstaetter et al., J. Pathol., 2019, DOI:10.1002/path.5281

3D Cellular Architecture Affects MicroRNA and Protein Cargo of Extracellular Vesicles
Sara Rocha et al., Adv. Sci. 2018, 1800948; DOI: 10.1002/advs.201800948

A deep conical agarose microwell array for adhesion independent three-dimensional cell culture and dynamic volume measurement
Andreas R. Thomsen et al., Lab Chip, 2018, 18, 179; DOI: 10.1039/c7lc00832e

Proteome Profiling of Primary Pancreatic Ductal Adenocarcinomas Undergoing Additive Chemoradiation Link ALDH1A1 to Early Local Recurrence and Chemoradiation Resistance
V. O. Oria et al., Translational Oncology, Vol. 11, Issue 6, Dec. 2018; DOI.org/10.1016/j.tranon.2018.08.001

A binary approach to the colony forming assay: reliable and reproducible read-outs using the 3D CoSeedis™ Cologny Forming in chip Assay
Marco P. Leu et al., 2019, Download Whitepaper

Easy mass production of homogenous and uniform 3D spheroids for high-throughput screening applications
Marco P. Leu et al., 2020, Download Whitepaper