NEXEL

Applications

• Drug Discovery: Accelerate the identification and development of new therapeutic compounds.
• Disease Modeling: Create accurate models of human diseases for better understanding and treatment.
• Regenerative Medicine: Support the development of cell-based therapies for tissue repair and regeneration.
• Toxicology Studies: Assess the safety and efficacy of new drugs and chemicals.

Benefits

• Enhanced Research Accuracy: The hiPSC-derived cells provide a more physiologically relevant model, improving the accuracy of your research findings.
• Reduced Time and Cost: Streamline your research process with high-quality, ready-to-use cells, reducing the time and cost associated with cell culture and differentiation.
• Ethically Sourced: The cells are derived from ethically sourced human iPSCs, ensuring compliance with ethical standards and regulations.

Frequently Asked Questions

What types of hiPSC-derived cells are available from NEXEL?

• a variety of hiPSC-derived cell types, including cardiomyocytes, hepatocytes, and neural cells, to support diverse research applications.

How do hiPSC-derived cells differ from other cell products?

• • The are produced using Nexel's proprietary iPSC technology, ensuring high purity, viability, and consistency, making them ideal for advanced research applications.

References

2024

• Modeling acute myocardial infarction and cardiac fibrosis using human induced pluripotent stem cell-derived multi-cellular heart organoids. Cell Death & Disease. DOI: 10.1038/s41419-024-06703-9

2023

• Generation of multilineage liver organoids with luminal vasculature and bile ducts from human pluripotent stem cells via modulation of Notch signaling. Stem Cell Research & Therapy. DOI: 10.1186/s13287-023-03235-5

2022

• Development of human pluripotent stem cell-derived hepatic organoids as an alternative model for drug safety assessment. Biomaterials.
• Three-dimensional cardiac organoid formation accelerates the functional maturation of human induced pluripotent stem cell-derived cardiomyocytes. Organoid.
• Cyclic Stretching Induces Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes through Nuclear-Mechanotransduction. TERM.
• Therapeutic correction of hemophilia A using 2D endothelial cells and multicellular 3D organoids derived from CRISPR/Cas9-engineered patient iPSCs. Biomaterials.

2021

• Truncated Milk Fat Globule-EGF-Like Factor 8 Ameliorates Liver Fibrosis via Inhibition of Integrin-TGFβ Receptor Interaction. Biomedicines. DOI: 10.3390/biomedicines9111529
• Evaluation of cardiac safety using human pluripotent stem cell-derived cardiomyocytes. KALAS.
• Trends in the global organoid technology and industry: from organogenesis in a dish to the commercialization of organoids. Organoid. DOI: 10.51335/organoid.2021.1.e11
• Modulations of Cardiac Functions and Pathogenesis by Reactive Oxygen Species and Natural Antioxidants. Antioxidants. DOI: 10.3390/antiox10050760
• Human pluripotent stem-cell-derived alveolarorganoids for modeling pulmonary fibrosis and drug testing. Cell Death Discovery. DOI: 10.1038/s41420-021-00439-7

2020

• Alterations of Ca2+ signaling and Ca2+ release sites in cultured ventricular myocytes with intact internal Ca2+ storage. BBRC. DOI: 10.1016/j.bbrc.2020.04.059
• Human Embryonic Stem Cell-Derived Wilson’s Disease Model for Screening Drug Efficacy. MDPI Cells. DOI: 10.3390/cells9040872

2019

• Synthetic probes for in vitro purification and in vivo tracking of hepatocytes derived from human pluripotent stem cells. Biomaterials. DOI: 10.1016/j.biomaterials.2019.119431

2018

• Rho-associated kinase inhibitor enhances the culture condition of isolated mouse salivary gland cells in vitro. Tissue and Cell. DOI: 10.1016/j.tice.2018.07.002

2017

• Current Understanding of Stem Cell and Secretome Therapies in Liver Diseases. Tissue Eng Regen Med. DOI: 10.1007/s13770-017-0093-7

2016

• Enhancing a Wnt-Telomere Feedback Loop Restores Intestinal Stem Cell Function in a Human Organotypic Model of Dyskeratosis Congenita. Cell Stem Cell. DOI: 10.1016/j.stem.2016.05.024

2015

• The Msi Family of RNA‒Binding Proteins Function Redundantly as Intestinal Oncoproteins . Cell Reports. DOI: 10.1016/j.celrep.2015.11.022.

2014

• Mitochondrial Induced and Self‒Monitored Intrinsic Apoptosis by Antitumor Theranostic Prodrug: In Vivo Imaging and Precise Cancer Treatment . JACS. DOI: 10..1021/ja510421q

2013

• Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells . Cancer Cell. DOI: 10..1016/j.ccr..04..008

2012

• Direct and Indirect Contribution of Human Embryonic Stem Cell‒Derived Hepatocyte‒Like cells to Liver Repair in Mice DOI: . Gastroenterology. DOI: .1053/j.gastro..11..030