A recent study published in the European Journal of Nutrition by Hedegger, Hommel, Schaubeck et al. explores the impact of different infant formulas on intestinal immune responses. This research contributes valuable insights into the immunomodulatory properties of early-life nutrition and its role in gut health.
PELOBiotech Products in Action:
- Primary Intestinal Epithelial Cells (P-IECs)
- Complete Epithelial Growth Medium with Supplements
IFs containing intact protein and L. fermentum CECT5716 activated TLR9 in HEK-Dual cells, but the functional components lactoferrin, L-5-methyltetrahydrofolate, and hydrolyzed whey proteins failed to activate TLR9. In P-IECs, the IFs induced increased phosphorylation of MAPK8/9 of the TLR signaling pathway and significantly reduced IL6 levels. Consistently, IL6 levels were increased in P-IECs when TLR9-signaling was inhibited. Interestingly, L. fermentum CECT5716 enhanced TLR9-signaling and increased NF-kappa-B inhibitor alpha-phosphorylation.
They found out that the used control formula, prebiotic formula, prebiotic formula with hydrolyzed-protein, and L. fermentum CECT5716 reduce IL6 levels in human P-IECs through TLR9 activation. L. fermentum CECT5716 and the here tested IFs could be a promising approach for modulation of gut health in infants.
Key Findings of the study:
- TLR9 Activation: Infant formulas activated Toll-like receptor 9 (TLR9) in vitro.
- IL-6 Suppression: Interleukin-6 (IL-6) levels were reduced in human primary intestinal epithelial cells.
- Insights for Nutrition Science: The findings contribute to understanding the immunomodulatory properties of infant formulas.
The Future of Gut Health Research
Understanding the immune interactions of intestinal epithelial cells opens new possibilities for developing optimized infant nutrition and therapeutic strategies targeting early immune development. This study lays the work for further research into how dietary components affect gut health and immune function from infancy.
Congratulations to the authors for advancing knowledge in gut immunology and nutritional science!
Read the full study here: [Link]
Explore how PELOBiotech’s cells and media support research: [Link]
#GutHealth #Immunology #PELOBiotech #IntestinalEpithelialCells #EuropeanJournalOfNutrition
