PELOPaper: Cellovations® Lung Fibroblasts to Create 3D Vasculature-on-Chip Models

From chb 25. November 2024 2 min
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A recent study published in Advanced Materials Technologies highlights Cellovations® products in advancing tissue engineering and microfluidic models. Researchers developed a perfusable multi-hydrogel vasculature-on-chip system that mimics complex human vascular structures.

The paper "A Perfusable Multi-Hydrogel Vasculature On-Chip Engineered by 2-Photon 3D Printing and Scaffold Molding to Improve Microfabrication Fidelity in Hydrogels" is an important step forward in replicating complex human systems for biomedical research.

This innovative method combines two-photon polymerization and hydrogel molding to create advanced vascular structures without exposing cells to cytotoxic processes. The study shows the great potential of Cellovations® products in replicating human systems for high-quality research.

Key Products and Results:

  • Cellovations® Human Lung Fibroblasts (HLF): Cultured with our specialized Fibroblast Growth Medium Enhanced, providing a stable co-culture for 10 days.
  • HUVECs (Human Umbilical Vein Endothelial Cells): Supported by Endothelial Cell Growth Medium Enhanced, demonstrating robust growth and scaffold invasion.
  • Speed Coating: Promoted adhesion and hydrogel scaffold fidelity. The study showcases an innovative approach combining 2-photon polymerization and scaffold molding, paving the way for precision vascular modeling and enhanced microfabrication

Congratulations to the authors and research team: Federico Cantoni, Laurent Barbe, Hannah Pohlit and Maria Tenje.

Read the full paper here: https://doi.org/10.1002/admt.202300718

#BiomedicalResearch #Cellovations #TissueEngineering #Microfluidics #InVitroModel

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