SynVivo

SynVivo is a specialist in creating microfluidic organ-on-chip platforms.

SynVivo creates physiologically realistic microvascular networks with accurate flow, shear stress, and pressure conditions that allow researchers to study cellular behavior, drug delivery, and disease mechanisms in real-time. The chips support human cell cultures that maintain biological phenotypes closer to in vivo tissues than conventional culture methods, enabling applications in oncology (tumor invasion and metastasis), neurology (blood-brain barrier transport), inflammation (immune cell interactions), and personalized medicine approaches using patient-derived cells.

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Microvascular network chips for monoculture - network 002, 100μm depth (set of 3)

Supplier
SynVivo

Catalog Number
PB-SV-104002

More Details

Microfluidic chip platforms

Linear Channels
SynVivo's linear channel chips feature three parallel channels per chip with various width options (100μm, 250μm, or 500μm) designed to study shear stress effects based on channel size and flow rates. These chips are used for investigating cell/particle adhesion and cell-cell or cell-particle interactions at the micro-circulation scale, serving as a substitute for parallel plate flow chambers with over 90% savings in consumables.

Bifurcating Channels
Bifurcating channel chips offer symmetric and asymmetric configurations with various bifurcation angles (15°, 30°, 45°, or 60°) and different parent/daughter channel widths. Researchers use these to study how bifurcation geometry affects cell/particle adhesion at vessel branch points and to compare adhesion patterns between linear sections and bifurcations simultaneously.

Microvascular Network Chips
These chips replicate physiologically realistic microvascular network architectures based on actual tissue vascular images, enabling researchers to investigate flow and morphology effects on drug delivery, cellular behavior, and obtain shear-adhesion maps within a single experiment.

Idealized Co-Culture Networks
Idealized network chips (IMN2 and IMN3 configurations) feature a central chamber surrounded by outer channels separated by barriers (slit or pillar designs with 3μm or 8μm pore sizes). These designs allow researchers to study cell-cell interactions, perfusion versus diffusion-based transport, and barrier formation across interfaces.

High Capacity

High Functional Group

Density

Multi-Point Covalent Attachment

High Specificity

HTS Compatible

3D Tissue and Organ-on-Chip Models

SynBBB (Blood-Brain Barrier Model)

SynBBB recreates the blood-brain barrier with accurate hemodynamic shear stress and enables real-time visualization of drug transport, cellular interactions, and barrier functionality. The platform is available in IMN2 radial, IMN2 linear, and 3PLEX configurations. A new SynTEER configuration features embedded electrodes for real-time transepithelial electrical resistance (TEER) measurements, launched in collaboration with World Precision Instruments as the EVOM-Chip system, enabling continuous barrier integrity monitoring across up to 12 channels simultaneously without disrupting cell health.

SynTumor (Cancer Model)

SynTumor platforms recreate the tumor microenvironment with physiologically leaky vasculature and side-by-side architecture for quantitative real-time visualization. The system supports monoculture (tumor cells alone), co-culture (with endothelial cells), and tri-culture (with stromal cells) configurations. Applications include drug delivery and efficacy screening, tumor intravasation/extravasation studies, tumor-immune cell interactions, and CAR-T cytotoxicity assessment.

SynRAM (Inflammation Model)

SynRAM enables simultaneous visualization of rolling, adhesion, and migration of immune cells in a single experiment under physiological flow conditions within microvascular environments. The platform features in vivo-like vascular morphology with fully formed lumen and co-culture capability for studying cell-cell interactions during inflammatory processes.

SynALI (Air-Liquid Interface Lung Model)

SynALI chips feature a central chamber flanked by microchannels that create air-liquid interface models mimicking lung architecture. The platform allows researchers to study respiratory epithelium, drug inhalation, and pulmonary disease mechanisms with physiologically relevant air exposure conditions.

SynTox (Toxicology Model)

SynTox models histological tissue slices under dynamic flow conditions to evaluate candidate drugs for organ-specific toxicity responses. The universal platform can be configured to model architecture specific to different organs while enabling real-time monitoring of cellular responses and compatibility with standard analytical instruments including omics methodologies.

Supporting Instruments and Accessories

SynVivo provides complete workflow solutions including pneumatic priming devices for cell seeding, programmable syringe pumps, stage-top incubators for live-cell imaging, and cell impedance analyzers.