Ellis Bio are experts in DNA methylation
Ellis Bio is specializing in innovative solutions for DNA methylation analysis, offering superior bisulfite conversion kits that set new standards in low-input methylation detection. Advanced Bisulfite Conversion Technologies
Ellis Bio provides two bisulfite conversion product lines designed to deliver gentle yet highly efficient DNA methylation analysis.
SuperMethyl Fast: The fastest bisulfite conversion method available, completing C-to-U conversion in just 35 minutes. This ultra-mild, high-efficiency approach minimizes DNA degradation and false positives while supporting very low DNA inputs, including cfDNA, FFPE-derived DNA, and forensic trace samples.
SuperMethyl Max: Featuring ultra-mild bisulfite conversion chemistry that surpasses enzyme-based methods, SuperMethyl Max excels in recovering high-quality DNA libraries with longer insert sizes and superior accuracy. It supports ultra-low input samples down to 100pg and is well-suited for challenging samples such as single cells, ancient DNA, and liquid biopsies.
| Feature | SuperMethyl™ Max | WGBS (Illumina) | Nanopore | EPIC Array |
|---|---|---|---|---|
| Min. DNA Input | 100 pg | 100 ng – 1 µg | ≥1 µg intact | 250 ng |
| FFPE / cfDNA Compatible | ✅ Yes | ⚠️ Limited | ❌ No | ⚠️ Limited |
| Conversion Efficiency | >99.8% | ~95–99% | N/A (direct) | N/A |
| DNA Damage | Minimal (UMBS) | High | None | N/A |
| CpG Genome Coverage | Whole genome | Whole genome | Whole genome | ~850k sites only |
| Workflow Time | ~2–3 hours | 1–2 days | Days + GPU compute | 1 day |
| False Positive Rate | Up to 6× lower | Standard | Low | N/A |
Why Choose Ellis Bio?
- Speed and sensitivity: SuperMethyl Fast accelerates your workflow with up to 10x faster conversion times compared to traditional methods without compromising accuracy.
- High DNA integrity and yield: Both product lines maintain DNA integrity by using ultra-mild reaction conditions, ensuring optimal downstream analysis.Broad Application Spectrum: Perfect for methylation studies in cancer research, epigenetics, single-cell analysis, forensic biology, and more.
- Ease of use: Ready-to-use reagents and simplified protocols enable rapid integration into your lab workflow.
