THT Biomaterials offers a suite of fully human, animal-component-free extracellular matrix coatings and substrates tailored for advanced cell culture and tissue engineering. Founded by Johannes Hackethal (see pic), their portfolio includes native human Collagen I and IV in both solution and freeze-dried formats (with pre-coated well plates available), native human Laminin-111 solution, and human placenta-derived substrates provided as liquid coatings or freeze-dried ECM. These products facilitate xenofree cell adhesion, survival, and function in in vitro models and bioprinting applications by delivering physiologically relevant, human-sourced matrix components.
THT Biomaterials specializes inhuman-derived extracellular matrix (ECM) componentsdesigned for xenofree cell culture and tissue engineering. These products enable fully human, animal-component-free coatings and hydrogels to improve cell attachment, viability, and functionality in in vitro models and bioprinting systems. Their key products fall under three major categories:
Native human collagens
Human Collagen I and IVas thebackbone fortissue-relevant cellsystems. Collagen I coatingsand hydrogelsthe densenetworkskin, bone, and connective, supportingalignment, osteogenic differentiation, and mesenchymal stem cell. Collagen IV, a major basementcomponent, fosters endothelialformation, epithelial barrier, and-on-chipby providingspecializedcues requiredvascularepithelialadhesionpolarization.
Collagen I, Solution (THT0101), Freeze-Dried (THT0102), Pre-coated Well Plates at Defined Concentrations (THT0103), Collagen IV, Solution (THT0104)
Native human laminin
Laminin-111 is pivotal for modeling early developmental niches and neuromuscular junctions. Its trimeric glycoprotein structure promotes the survival, migration, and differentiation of pluripotent stem cells into neuronal, muscle, and endothelial lineages. Laminin-111 coatings enhance organoid formation, neural network development, and satellite cell self-renewal in muscle-regeneration studies.
Laminin-111, Solution (THT0201)
Human placenta derived substrates
Placenta ECM preparations capture a complex mixture of collagens, laminins, proteoglycans, and glycoproteins in their native conformation. These substrates support wound-healing assays, angiogenesis models, and immune-cell migration studies by recreating the diverse biochemical and biomechanical environment of the placental niche. They are particularly valuable for 3D bioprinting of multicellular constructs and for investigating trophoblast invasion, maternal-fetal interface biology, and placental pathologies.
Placenta Substrate, Liquid (THT0301), Placenta ECM, Freeze-Dried (THT0302)
