New Products | Automated cell culture fluid management system
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From KAb
Signata CT-5®: Flexible Fluid Management for Cell and Gene Therapy Workflows
Discover the Signata CT-5® — a flexible, closed fluid management system designed to bring automation, consistency, and control to cell and gene therapy workflows.
Built for final fill, media formulation, fluid transfer, and bioreactor fill/wash applications, the Signata CT-5® helps reduce manual handling, protect high-value materials, and support more efficient processing from development through manufacturing.
What Is the Signata CT-5® Used For?
The Signata CT-5® is used to automate key fluid handling steps in cell and gene therapy manufacturing. It is designed to support closed, controlled transfer of valuable biological materials between multiple input and output containers.
It can be used for final fill, helping transfer cell therapy products into cryobags or CellSeal® Cryogenic Vials with improved consistency and reduced manual handling.
It is also used for media formulation, allowing users to mix media, buffers, reagents, or process solutions from multiple sources and prepare aliquots for downstream manufacturing steps.
The system can also support bioreactor fill and wash workflows, helping move fluids in and out of connected systems while maintaining a more controlled process.
Because the Signata CT-5® is designed for flexible fluid management, it is useful for teams that need automation without losing process flexibility. It can support both small-volume and larger-volume workflows, making it suitable for process development, clinical manufacturing, and commercial cell therapy production.
Applications of the Signata CT-5®
One of the key applications of the Signata CT-5® is final fill. In cell therapy manufacturing, the final product often needs to be transferred into cryobags, cryogenic vials, or other storage containers before freezing, storage, or shipment. The Signata CT-5® can help automate this step, reducing manual handling and supporting a more consistent filling process. This is particularly important when working with high-value cell therapy products, where accuracy, sterility, and product recovery are critical.
Another important application is closed-system fluid transfer. The system can be used to move fluids between multiple containers while helping maintain a controlled processing environment. This makes it relevant for workflows where reducing contamination risk is important, such as GMP manufacturing, clinical production, and advanced therapy development.
The Signata CT-5® can also be used for media and reagent formulation. It supports the transfer and mixing of fluids from different input sources, helping users prepare media, buffers, reagents, or process solutions for downstream steps. This can improve workflow efficiency and reduce repetitive manual pipetting, connection changes, or tubing manipulation during production.
In cell and gene therapy manufacturing, the system can support processes that require accurate fluid distribution into multiple final containers. This is useful for both autologous therapies, where each batch may be patient-specific, and allogeneic therapies, where larger batch sizes may need to be divided into multiple doses or storage formats.
The Signata CT-5® is also relevant for process development and scale-up. During early development, teams often need flexible systems that can adapt as protocols change. As processes move toward clinical or commercial manufacturing, automation becomes increasingly important for improving repeatability, documentation, and workflow control. The Signata CT-5® can help bridge this transition by supporting both development-stage and manufacturing-stage fluid handling needs.
Another application is in bioreactor fill and wash workflows. The system can help transfer media, buffers, or wash solutions into and out of connected systems. This can support preparation, feeding, washing, or downstream handling steps where controlled fluid movement is needed.
The Signata CT-5® may also be used in cryopreservation preparation, where cell products must be combined with cryoprotective media and then filled into final storage containers. In these workflows, controlled and consistent fluid handling is important to help maintain product quality before freezing.
Key Application Areas
Final fill of cell therapy products
Filling into cryobags and CellSeal® Cryogenic Vials
Closed-system fluid transfer
Media, buffer, and reagent formulation
Cryopreservation preparation
Bioreactor fill and wash steps
Aliquoting into multiple final containers
Autologous and allogeneic therapy workflows
Process development and scale-up
GMP and clinical manufacturing
Reduction of repetitive manual handling
Support for more consistent and controlled workflows
Who Is It Relevant To?
The Signata CT-5® is especially relevant to cell and gene therapy developers, biopharmaceutical companies, CDMOs, GMP manufacturing teams, and process development groups.
It is useful for organisations working with high-value cell products where contamination control, process consistency, documentation, and efficient handling are important.
For early-stage developers, it can help introduce automation sooner in the workflow. For clinical and commercial manufacturers, it supports more controlled, repeatable, and scalable processing.
Overall, the Signata CT-5® is useful wherever closed, automated, and flexible fluid transfer is required in advanced therapy workflows.
