‘Totipotent’ SC capable of forming Viable Embryo

#Stem cells with characteristics of totipotency — capable of creating all the tissue types needed to build and sustain an embryo — have been created in mice by a California-led research team.

Researchers found that a #microRNA called miR-34a prevents totipotency. Pluripotent mouse cells deficient in that microRNA acquired signs of totipotency.

The feat makes it feasible to explore the molecular basis of totipotency, said the researchers in a study, that was led by Yong Jin Choi and Chao-Po Lin of UC Berkeley. Lin He, also of UC Berkeley, was the senior author. It can be found at j.mp/totipot.

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