Rethinking Regeneration: Empowerment of Stem Cells by Inflammation

The ontogenetic development and maintenance of tissue homeostasis at the cellular level are accomplished by regulating the activation, renewal, expansion and differentiation of stem cells. The differentiation and regeneration potential of stem cells has been well studied in both preclinical and clinical investigations. In recent years, a series of experiments have revealed that replacement of damaged or defective cells by exogenously administered stem cells is critical in achieving their therapeutic effects in various diseases, such as multiple sclerosis (MS).

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