Reprogramming Adult Cells in vivo to Treat Parkinson’s

Reprogramming of #iPSCs has given rise to the emergence of #reprogramming approaches that target other types of cells including those of meso-, endo- and ectodermal origin — for example, the generation of functional neurons from fibroblasts which has been reported in a number of recent studies. These are, potentially, therapeutically powerful strategies to target severe and elusive diseases.

One such disease is #Parkinson’s, a disorder of the nervous system affected by the death of neurons and impaired dopamine signaling. Work from the Karolinska Institutet with collaborators at Stanford University, the University of Vienna and Malaga University described, for the first time, a new approach to treating Parkinson’s which merges cell therapy alongside genetic reprogramming of cells for enhanced therapeutic targeting.
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