Archive for Category: General

Showing 61 – 70 of 104 results

  • Amyloid Deposits Not Always Toxic to Cells

    How do protein aggregates damage cells? Scientists believe they are toxic themselves, or that they sequester other proteins that have an essential cellular function. In the November Science, researchers led by Frederic Rousseau and Joost Schymkowitz at VIB Switch Laboratory, Leuven, Belgium, add evidence for the latter. They designed a synthetic peptide consisting of an amyloidogenic fragment of vascular endothelial growth factor receptor 2 (VEGFR2). When added to endothelial cell cultures, which...
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  • Researchers describe Bone Marrow SC Population with Potential for repeat Transplantation

    A new study demonstrates that non-blood cell forming stem cells present in human bone marrow play an important role in maintaining the hematopoietic microenvironment, and these stromal cells appear to retain full self-renewal potential after primary and secondary transplantations, according to an article published in Stem Cells and Development. To read more, please click here.
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  • Embryonic SCs and Fetal Tissue Research— will Trump Intervene?

    Of all the materials valued in biomedical research, embryonic stem (ES) cells and fetal tissue have gotten disproportionate attention from politicians. Because creating ES cell lines initially requires destroying a human embryo, President George W. Bush tightly restricted the use of federal funds for research on all but a few stem cell lines. President Barack Obama then made lifting those restrictions one of his first official actions after he took office in 2009. More recently, accusations that...
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  • New Product: Human iPSC-Derived Neural Stem Cells (i-HNSC)

    Human iPSC-Derived Neural Stem Cells (i-HNSC) are homogeneous, self-renewing and multipotent. Through partnership with leading stem cell company StemoniX, the cells are produced using next generation manufacturing technology. The result is large quantities of quality cells produced from each donor in a short period of time, cost effectively. Excellent Cell-Based Research Model Neural Development Neurotoxicity Lineage Differentiation Electrophysiology Disease modeling Drug discovery...
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  • Wash your cloths, now: Dirty Laundry may cause Environmental Contamination

    A new paper published in FEMS Microbiology Letters, resulting from an investigation of a laundry facility that services several Seattle-area hospitals, suggests that soiled clinical linens may be a source of surface Clostridium difficile contamination. C. difficile is a hospital and community acquired pathogen. C. difficile are spore-forming anaerobic bacteria that have been identified in 2-3% of healthy, non-hospitalized adults and in 10-25% of hospitalized adults. Toxin-producing C. difficile...
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  • Deep Insights: Let´s have a Look at the Marihuana Receptor

    Crystal Structure of the Human Cannabinoid Receptor CB1 Cannabinoid receptor 1 (CB1) is the principal target of Δ9-tetrahydrocannabinol (THC), a psychoactive chemical from Cannabis sativa with a wide range of therapeutic applications and a long history of recreational use. CB1 is activated by endocannabinoids and is a promising therapeutic target for pain management, inflammation, obesity, and substance abuse disorders. Here, we present the 2.8 Å crystal structure of human CB1 in complex with...
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  • PELOBiotech: EASY – New Endothelial Medium launched

    We are happy to launch our EASY Endothelial Cell Growth Medium and offer you best value for the best price. We call this medium Easy, because it´s an easy choice – just get TOP quality for your cells at an irrestible TOP price. EASY has been developed for the special needs in basic research groups. “We use this easy-to use medium in our daily routine and are thrilled”, says our CSO, Dr. Lothar Steeb. “That´s why we decided to ease the access to it with an all-beating price.” It´s...
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  • The Promise of Cell Therapy in the Clinic: Can the Media be an Ally?

    Even a cursory glance at general media over recent weeks would have indicated an increased amount of coverage dedicated to immunotherapy. Partly linked to recent developments in the filed, most major outlets have, in the past few months, chimed in, in one way or another, in a response to the major headlines. As an example, this week, the New York Times asked “What Is Immunotherapy?” in an article that followed on from recent NY Times reports commenting on the recent stem cell clinic data and...
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  • Regenerative Medicine Improves Strength and Function in Muscle Injuries

    Results of a study conducted by researchers at the University of Pittsburgh School of Medicine and the McGowan Institute for Regenerative Medicine showed significant improvement in strength and range of motion, as well as evidence for skeletal muscle regeneration, in 13 patients who were surgically implanted with bioscaffolds derived from pig tissue to treat muscle injuries. The patients had failed to respond to conventional treatment before use of the extracellular matrix (ECM). To read more,...
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  • Controlled Release H2S Delivery System Protects graft Endothelium

    Hydrogen sulfide (H2S) functions as a protective gas transmitter in various physiological and pathological processes, but the lack of ideal donors severely hampers the clinical application of H2S. This study aims to construct a controlled release H2S donor and evaluate its protective effect on graft endothelium. Mesoporous silica nanoparticles (MSNs) were synthesized using the sol–gel method and loaded with diallyl trisulfide (DATS), an H2S-releasing agent named DATS-MSN. In vitro experiments showed...
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