Zarebkohan et al., Eu J Pharm Sci
The blood–brain barrier inhibits drugs and genetic material from reaching the brain, challenging the development of efficient carriers. This study targets DNA to brain tissue using a novel gene delivery system. A peptide was linked on dendrimers, and DNA was loaded in functionalized nanoparticles, followed by biodistribution analysis. The nanoparticles exhibit good transfection efficacy with low toxicity, and CAI-supplied brain capillary endothelial cells internalize the nanoparticles by endocytosis. The results suggest such nanoparticles might provide safe, effective gene delivery to the brain.