Synthetic Hydrogels

Be smart – go synthetic

Noviocell – the synthetic smart hydrogel for your 3D cell culture

Noviocell has established a smart synthetic hydrogel for 3D Cell Culture ranging from organoid growth to personalized medicine. These hydrogels can easily change their physical condition enabling easy-to-use 3D cell culture products.

Noviogel

Noviogel is a bioelastic reversible thermosensitive synthetic solution for 3D Culture based on Polyisocyanopeptide (PIC) hydrogel, a new class of advanced polymers. PIC hydrogel is an improved platform for cell studies, because it combines the unique benefits of natural and synthetic biomaterials. PIC hydrogels uniquely perform like collagen, while possessing the same characteristics as other commercial hydrogels.

  • fully reversible thermo sensitive
  • cells can be recovered easily

 

Syntrix

Noviocell Syntrix is a synthetic, bioactive cell culture matrix based on self-assembling hydrogel technology. Gels form rapidly and spontaneously under physiological conditions from appropriate precursor solutions, allowing mild encapsulation of cells.

 

  • presenting a low-adhesion surface to cells
  • enhances cell adhesion and performance

 

 

Features

  • Synthetic

No batch to batch variation and your clinical solution

 

  • Bio-elastic

Polymer fiber elasticity the same as human collagen bundles

 

  • Organoid, Spheroid Cell Harvesting

Reversible thermosensitive: at 4°C a solution, at 37°C a hydrogel

 

  • Ready-To-Use

Just mix solution with your cells and you are done

 

  • Transparent

Optically clear imaging with no background

 

Some Appl:

  • Drug screening
  • Regenerative medicine
  • Stem cell & cell differentiation
  • Cell migration
  • Cell/Organoid Culture
  • Cell/Organoid Encapsulation

Products:

Noviogel-P  

Noviogel-P1K (PB-NCN01) and Noviogel-P1K (PBNCN02) are  the pure PIC without any functionalization (has no additional (growth or ECM) peptides coupled to the hydrogel)

Noviogel-RGM

Noviogel-RGD1k (PB-NCN03)  and Noviogel-RGD5k (PB-NCN04)

PIC functionalized by RGM peptides (The most widely studied adhesive peptide in the biomaterials field is the tri-amino acid sequence, arginine-glycine-aspartate, or “RGD” . RGD is the principal integrin-binding domain present within ECM proteins such as fibronectin, vitronectin, fibrinogen, osteopontin, and bone sialoprotein.

1K or 5K: Different polymer length which has influence on the strain stiffening  (sigma C) of the polymer bundle.

Syntrix-P: (PB-NCS01) is functionalized with oligoethyleneglycol moieties, thereby presenting a low-adhesion surface to cells.

Syntrix-BM: (PB-NCS02) is functionalized with a number of bioactive peptides to enhance cell adhesion and performance  (Laminin, Fibronectin, Collagen I, Collagen IV, Vitronectin)

Cells & Organoids cultured in Noviogel or Syntrix:

  • Neural cells
  • Cardiomyctes
  • Muscle cells
  • Liver cells (HepG2)
  • HUVEC
  • Tumor cells & tumor associated fibroblast
  • Macrophages

 

  • Liver organoids
  • Intestine organoids (jejunum)